Advanced Innovations by Alphascience Research
DISCOVERY OF A LONGEVITY INGREDIENT: TANNIC ACID
Tannic acid is an outstanding ingredient, a polyphenol issued from nature. Tannic acid is particularly present in the bark of Sequoia to protect it from diseases, parasites and fungi, this explains the Sequoia’s exceptional lifespan: some specimens may well exceed 3,000 years.
The antioxidant activity of tannic acid is mainly attributed to its redox properties, which allow him to act as reducing agent, hydrogen donor and singlet oxygen quencher. In addition, it possesss metal chelation properties 
The polyphenolic nature of tannic acid (hydrophobic core and hydrophilic shell) is also responsible for its antioxidant action .
These properties make it a unique ingredient for:
- Iron chelating complexion
- Hydrogen peroxide and free radicals scavenger
- Powerful antioxidant
- Superoxide anion radical scavenger
- Strengthens blood vessels epithelium
- Regulates pigmentation
- Enhances collagen synthesis
For the first time, Alphascience has managed to use highly concentrated Tannic Acid in its formulations to protect, restore and maintain the integrity of skin cells for exceptional protective results.
STABILIZATION OF L-ASCORBIC ACID (VITAMIN C)
In its natural form (L- ascorbic acid), vitamin C is one of the most effective anti-aging ingredients but also the most unstable. It is one of the most powerful anti-free radicals able to protect from oxidative factors responsible for the premature aging of the skin.
On the surface of the skin, it boosts the proliferation of keratinocytes for an immediate and visible action on the complexion and hyperpigmentation, it is also able to penetrate the dermis to significantly boost collagen synthesis and reduce wrinkles.
HOW DO WE STABILIZE VITAMIN C?
Thanks to its control of the chemical characteristics of vitamin C, Alphascience has developed a technology based on a unique associative complex of powerful antioxidants which ensures the stabilization of highly concentrated L-ascorbic acid, even at high temperature:
FIRST STABILIZATION OF PURE L-GLUTAMINE
A sufficient supply of glutamine (NH2-CO-CH2-CH2-CH(NH2) COOH) is important for firm and supple skin. If not enough glutamine is available, the body takes the necessary protein from muscle mass and converts it to glutamine and energy. This leads to proteins being lost, muscle stands becoming thinner and the skin becoming generally saggy. This is why glutamine has been referred to as an « internal fountain of youth » by scientists.
Naturally present in the human body, glutamine is involved in collagen synthesis in direct stimulation and as a precursor of proline and hydroxyproline. Although glutamine is known as an important stimulator of collagen biosynthesis in collagen-producing cells.
In cultured cells, scientists found that glutamine is a potent collagen biosynthesis stimulator (it induces an increase in collagen biosynthesis of 400% after 12 hours of incubation).
- Increase nucleotide synthesis.
- Increase protein turn over in muscles by stimulation of proteasomes
- Antiglycation effect by stimulation of glycogenesis
- Direct effect on cicatrization and inflammation
For the first time, GLUTAMINE has been stabilized by Alphascience and integrated in a delivery system which acts as a powerful collagen booster to reduce wrinkles and improve skin density.
NEUTRALIZATION OF POLLUTANTS: α-NO COMPLEX
The neutralization of air pollutants, aggravating factors for skin disorders.
The latest dermatological clinical studies show that air pollution combined with UV is responsible for 60% of premature aging of the skin.
It has also been demonstrated that the pollutants potentiate the harmful effects of sunlight by multiplying by 4 the UV radiation deleterious effects on skin cells and thereby increasing the photo-actinic damages: wrinkles, brown spots, melasma and skin sagging.
α-NO COMPLEX dual action:
Neutralizes the action of Reactive Oxygen Species (ROS), whose harmful action is stimulated by pollutants at the cellular level for a maximum anti-aging protective efficiency.
An action chelating of heavy metals (Fe, Pt catalysts), and complexation of the micro particles present in the pollution (NOx, O3, PM2.5).
 Rice-Evans, 1995 and Liyana-Pathirana and Shahidi, 2006
Isenburg et al., 2006
 Bellon G. et al., Glutamine increases collagen gene transcription in cultured human fibroblasts, Acta 1268, 311-323, 1995)
 Karna E. et al, The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts, Comparative Biochemistry and Physiology, Part B 130, 23-32 (2001)
 Pr HUMBERT P. Journal of Investigative Dermatology 2001